#sponsoredclick here - not for the smaller, portable toolboxes that you may take with you to a job site. The obvious solution is to keep them in your garage or your workspace so that you always have the tools that you need close at hand for woodworking, car repair projects and the like, but the positioning within the garage can also be important.
One thing to keep in mind is that most of these toolboxes do not come equipped with built-in lights, so you want to make sure that you set them up under your overhead lights. This way, when you are digging around for a certain size drill bit or something else small and elusive, you are not doing it in the shadows. You can also buy lights that can be installed right over the toolbox if you would like, but it is easiest to just pick a location that already has great visibility.
Another thing to consider is where you park your car. If you are like most people, you use the garage as much as a work space as you use it for a parking space. In the summer, you can just leave the car in the driveway and have all of that open space, but the winter may mean that you bring it inside far more often. You do not want to position the toolbox so that the car will be between your workbench and the box. This forces you to walk around the car every time that you need to get something, which, while it may not seem annoying at first, can really slow you down when you are working on a project.
Finally, you should consider any drains in the garage floor. If the toolbox is on wheels, you can put it over a drain without worrying about blocking it. If it is not on wheels, though, you must make sure that you do not block the drain. Not only will the drain not be able to work when you wash the car, but the water may still move to that low point and pool around the toolbox.